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Here, the loss of Tff1 typically leads to an inflammatory response followed by the classical dysplasia-adenocarcinoma sequence .In line with this, celecoxib, a selective Cox-2 inhibitor and non-steroidal anti-inflammatory drug disturbed the integrity of the adenoma by promoting ulceration and inflammation [26,27].
The non-transformed rat gastric epithelial cell line RGM-1  (kindly provided by Dr. Before scratch-wounding, cultures were incubated in serum-free, supplemented growth medium for 12-15 h.
A polyclonal rabbit antiserum was generated against the synthetic peptide FHPMAIENTQEEECPF representing the C-terminus of mouse Tff1.
This sequence has already been used successfully as antigenic determinant .
Results: Surprisingly, Tff1 expression was up-regulated in migratory cells.
No unequivocal signs of the epithelial-mesenchymal transition were detectable in migratory cells.